Neurodegenerartion comprises a group of diseases of major research interest but still is having increasing prevalence and mostly are practically incurable. Some herbal formulations used as traditional medicines to treat neurodegenerative disease worldwide are also briefly discussed. In this review we briefly discussed some medicinal plants which have neuroprotective activities against ND specially AD and PD along with its mechanism of actions behind their pharmacological activities. have major mechanisms behind management of most of the ND. Phytochemicals like Alkaloids, terpenes, saponins, phenols, flavonoids, etc. Herbals have been used from ancient times and referred to as conventional treatment methods to treat neurodegenerative disease having natural healing power and less side effects. Practically, ND are incurable but by therapeutic approaches the loss of neurons and progress of disease is controlled but these drugs are associated with many unwanted effects. Neurodegenerative disease (ND) like Parkinson’s Disease (PD) and Alziemer’s Diseases (AD) aving molecular complexity in pathogenesis resulting in prominent loss of normal physiology of an individual. Neuronal degeneration, characterized by progressive and irreversible loss of structure and function of neurons, could be a physiological age related or pathological intervention resulting in death of neuronal tissues.
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